Our aim was to study the relationship between environmental oxidants (present in our diet and the air and include second hand tobacco smoke) and genes.
Our principle hypotheses were:
- Asthmatic children with certain antixoidant genes will be at increased risk for troublesome asthma when exposed to environmental oxidants (including tobacco smoke and dietary vitamin E).
- Asthmatic children with filaggrin null mutations genes will be at increased risk for troublesome asthma when exposed to environmental oxidants (including tobacco smoke and dietary vitamin E).