Previous work by our group and others has found that children with a combination of certain genes and certain environmental exposures are at increased risk for developing asthma. The genes of interest are:
- Those which are know to make an individual more sensitive to increased oxidant stresses in the environment, eg tobacco smoke, or reduced antioxidant intake in the diet. These genes include GSTM and GSTP
- Those which we know are important to making the skin a strong barrier against exposures in the environment. Specifically this are the filaggrin genes.
Here we will see whether genetic risk factors and environmental exposures are linked to asthma severity (measured by amount of treatment needed) and asthma control (measured by level of symptoms).