Participants - What?

What is involved? Well as much or as little as you want. If you can fill in the asthma questionnaire and provide a sample of saliva (we can get some DNA from this) then we can get going.

We would also be very grateful if you could give us some or all of thefollowing pieces of information:

  1. A dietary questionnaire. This lets us studyhow diet may influence asthma and the role genes has to play in this. This can be completed at home.
  2. quality of life questionnaire This lets us understand how asthma affects a child's quality of life. This can also be completed at home.
  3. Skin allergy testing. The involves putting drops of water containing things people can be allergic to, eg dust mite, and then scratching the skin under the drop; this lets the water into the skin and if there is an allergy a midge-bite/nettle-sting type of small lumpwill appear for 20-30 minutes. We are testing severalallergens including dust mite, egg, cat hair, grass, mould and peanut. This will be done at the hospital.
  4. Breathing tests. In children over 5 years old we will do a breathing test called spirometry and then repeat this 15 minutes after taking two puffs of the blue inhaler. This will let us see if the airwaysare narrowed and if so whether the blue inhaled helps widen the airways.
  5. Salivary cotinine. This is a substance which is related to breathing in second hand tobacco smoke and lets us study how this exposure is related to symptoms.

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