Scientific Community - Aims and Hypotheses
- To phenotype children attending secondary care asthma clinics in Scotland
- To establish a clinical database
- To establish a biobank for storage of DNA collected from asthmatic children
- To study hypothesis driven gene-environment interactions within a population of asthmatic children in Scotland using a case-only design. Candidate genes will be the Arg16Gly polymorphism of the beta 2 adrenoceptor, filaggrin and antioxidant genes GSTTM and GSTTP. Environmental factors will include exposure to environmental tobacco smoke and dietary vitamin E intake.
- Are asthmatic children with genetically determined susceptibility to antioxidant stress and who are exposed to environmental oxidants (including tobacco smoke and dietary vitamin E) more likely to be non-atopic?
- What is the overall burden of filaggrin null mutations in Scottish asthmatic children? do these children represent a particularly difficult to treat subgroup and are they particularly vulnerable to individual environmental insults?
- Is bronchodilator response (BDR) attenuated in asthmatic children with homozygous genotype Arg16 and is this exaggerated by treatment with long acting beta agonists and palliated by treatment with leukotriene receptor antagonists?