Asthma is a common condition among children. The cause for childhood asthma is not fully understood but involves interactions between genetic and environmental factors. Childhood asthma is not a homogeneous condition. Our hypothesis is that interactions between different genetic and environmental factors are important to the heterogeneity of childhood asthma, and this is supported by our previous work.
The aims of this project are to phenotype 1000 asthmatic children and establish a DNA biobank to study gene-environment interactions; we have already identified a number of specific hypotheses to test. Asthmatic children under the care of respiratory paediatricians across Scotland are eligible. A standard methodology that we know is feasible and acceptable is being applied to collect data. A database has been established and maintained by experienced personnel. The establishment of the database is anticipated to extend current understanding of asthma heterogeneity.